Production and Quality Control of Ac-225 Radiopharmaceuticals
Closed for Proposals
Project Type
Coordinated Research ProjectProject Code
F22075
CRP
2272
Approved Date
20/10/2021Project Status
Active - OngoingStart Date
29/06/2022Expected End Date
01/09/2027Participating Countries
Argentina, Belgium, Brazil, Canada, Egypt, Greece, Indonesia, India, Iran, Islamic Republic of, Japan, Mexico, Peru, Pakistan, Poland, Saudi Arabia, Singapore, Thailand, Türkiye, United States of America, Uruguay, South AfricaDescription
TAT recently showed encouraging clinical results that stimulate significant attention from the research community, clinicians and professional societies. However, the main limitation for the wide application of TAT is the availability of suitable radionuclides as well as approved guidelines and protocols for production and quality control of these radiopharmaceuticals.?Due to the advances in the preparation and clinical application of alpha-emitter radiopharmaceuticals, esp. Ac-225, Member States have requested International Atomic Energy Agency (IAEA) to assist with capacity building and technology transfer for the development, production, and quality control of this new generation of therapeutic radiopharmaceuticals.
Specific Objectives
Quality control and quality assurance of alpha-emitter radioisotope (i.e. Ac-225) received from various sources
Production of alpha-emitter radiopharmaceuticals with focus on Ac-225 (small molecules, peptides, antibodies, etc.)
Quality control of alpha-emitter radiopharmaceuticals with focus on Ac-225 from various aspects
Preclinical studies on the final alpha-emitter radiopharmaceuticals with focus on Ac-225 including dosimetry, stability, cell studies, animal studies, possible side effects etc.
Preparation and formulation of appropriate protocols and guidelines accessible for all IAEA Member States