• <menu id="888u4"><menu id="888u4"></menu></menu>
  • Radiation Inactivation of Bio-hazards Using High Powered Electron Beam Accelerators

    Closed for Proposals

    Project Type

    Coordinated Research Project

    Project Code

    F23033

    CRP

    2220

    Approved Date

    08/11/2017

    Project Status

    Closed

    Start Date

    13/04/2018

    Expected End Date

    12/04/2022

    Completed Date

    30/06/2025

    Participating Countries

    Argentina, Brazil, Canada, Germany, Egypt, Hungary, Republic of Korea, Kuwait, Malaysia, Poland, Portugal, Tunisia, Türkiye, United States of America

    Description

    Radiation technology has emerged as an effective tool for decontamination of biohazards. It has been instrumental in improving the quality of human life through its proven effectiveness in sterilization of medical and healthcare products, and also for improving food safety. Over the years this technology has been primarily based on using gamma radiation sources like Co-60 as the radiation source. However, the emerging concerns regarding the safety and security of radioactive sources coupled with issues related to shipping such materials through normal supply chain process have encouraged industry to look for machine based electron beam radiation sources in future. To bring out the full potential of electron beams in these areas related to treatment of biohazards, it is important to establish a number of factors that include the kinetics of inactivation which is complicated on account of the variety of radiation sources, their dose rates, and energies as well as because of differences in the nature of microbes and their environment. This Coordinated Research Project (CRP) relates to establishing the kinetics of inactivation of microbes at high dose rates so as to use electron beam technology for inactivation of biohazards.

    Objectives

    Formulate guidelines to enhance and strengthen use of electron beam accelerators for treatment of biohazards of concern under changing conditions such as at high dose rates, different ambient conditions, and varying substrates in applications such as radiation sterilization, hygienization of bio-solids, sanitizing infectious hospital waste or toxic effluents and eliminating deliberate biohazards.

    Specific Objectives

    Demonstrate treatment of biohazards using electron accelerators.

    Develop validation procedures for the processes of treating biohazards at high dose rates

    Develop guidelines for treatment of biohazards using electron beam accelerators

    Dose setting procedures appropriate to specific bio contaminants.

    Provide reliable data about radiation inactivation of pathogenic microorganisms and other bio contaminants under varying physical conditions.

    Develop appropriate methodologies for treatment of biohazards using electron beam accelerators

    Impact

    The impact of the CRP F23033, aimed at enhancing and strengthening the use of electron beam (e-beam) accelerators for treating biohazards is multifaceted. First of all, it was clearly demonstrated that electron beam accelerators effectively kill bacteria, viruses, and other pathogens by damaging their DNA/RNA, preventing reproduction. This technology can be used to disinfect medical supplies, protective equipment, and even wastewater, providing a rapid method to control pathogens. By treating biohazardous materials (such as medical waste or contaminated animal products) with e-beams, the spread of infectious diseases, which is crucial in preventing pandemics, can be significantly reduced. Second, as e-beam sterilization is a clean process, it significantly reduces the need for harsh chemicals (e.g., ethylene oxide, formaldehyde) traditionally used in sterilization. This minimizes the release of toxic byproducts, which is beneficial for both the environment and human health. Accelerated biodegradation of organic waste, like animal or plant byproducts, can help manage waste efficiently. Treated bio-waste can even be reused safely, potentially as fertilizer or other byproducts, contributing to a circular economy model. In addition, electron beam technology proved to be useful for food sterilization as it reduces or eliminates pathogens without significant alteration to the food's properties or nutritional content. This enhances food safety, shelf life, and supports export quality standards. Finally, this project encouraged the development of scalable, cost-effective e-beam technology, supporting new applications and research, from industrial sterilization to experimental treatments for other contaminants (e.g., pharmaceutical residues).

    Relevance

    This CRP is relevant to several IAEA topics (see below) and other CRPs, for example F23034, F23035, and D61025

    CRP Publications

    Brazil, IPEN
    Research article
    2021
    A research article on "Mycoflora and DNA sequencing analysis of radioresistant fungi isolated from irradiated vehicular air conditioning filters collected in S?o Paulo, Brazil"
    Portugal, C2TN
    Research article
    2020
    A research article on "Effect of Gamma-Radiation on Zearalenone—Degradation, Cytotoxicity and Estrogenicity"
    Germany
    Journal Article
    2019
    Eimeria tenella oocysts attenuated by low energy electron irradiation (LEEI) induce protection against challenge infection in chickens
    Portugal, C2TN
    Research article
    2020
    A research article on "The use of gamma radiation for extractability improvement of bioactive compounds in olive oil wastes"
    USA
    Journal Article
    2019
    A Comparative Analysis of the Metabolomic Response of Electron Beam Inactivated E. coli O26:H11 and Salmonella Typhimurium ATCC 13311
    Canada
    Journal Article
    2020
    Potential synergistic antimicrobial efficiency of binary combinations of essential oils against Bacillus cereus and Paenibacillus amylolyticus-Part A
    USA, TAMU
    Research article
    2018
    A research article on "Escherichia coli Cells Exposed to Lethal Doses of Electron Beam Irradiation Retain Their Ability to Propagate Bacteriophages and Are Metabolically Active"
    USA, TAMU
    Research Article
    2018
    A research article on "Benchmarking the minimum Electron Beam (eBeam) dose required for the sterilization of space foods"
    Brazil
    Journal Article
    2018
    Emerging pollutants, related toxicity, and water quality decreasing: Tannery, textile, and pharmaceuticals load pollutants
    Hungary
    Conference Paper
    2019
    Preventing the Development of Antibiotic Resistance in Wastewater Matrices by High Energy Irradiation
    USA
    Journal Article
    2018
    Escherichia coli Cells Exposed to Lethal Doses of Electron Beam Irradiation Retain Their Ability to Propagate Bacteriophages and Are Metabolically Active
    Brazil
    Journal Article
    2021
    Mycoflora and DNA sequencing analysis of radioresistant fungi isolated from irradiated vehicular air conditioning filters collected in S?o Paulo, Brazil
    Canada
    Journal Article
    2020
    Effect of gamma-irradiation on the microbial inactivation, nutritional value, and antioxidant activities of infant formula
    Poland, INCT
    Conference presentation
    2020
    A conference presentation on "A METHOD OF HYGIENISATION AND DISINTEGRATION"
    USA, TAMU
    Research article
    2020
    A research article on "A critical review of ionizing radiation technologies for the remediation of waters containing Microcystin-LR and M. aeruginosa"
    Germany
    Journal Article
    2020
    Low-Energy Electron Irradiation Efficiently Inactivates the Gram-Negative Pathogen Rodentibacter pneumotropicus—A New Method for the Generation of Bacterial Vaccines with Increased Efficacy
    Portugal
    Journal Article
    2020
    Ionizing Radiation Technologies to Increase the Extraction of Bioactive Compounds from Agro-Industrial Residues: A Review
    USA
    Journal Article
    2020
    Benchmarking the minimum Electron Beam (eBeam) dose required for the sterilization of space foods
    Canada, Canadian Irradiation Centre
    Research article
    2020
    A research article on "Potential synergistic antimicrobial efficiency of binary combinations of essential oils against Bacillus cereus and Paenibacillus amylolyticus-Part A"
    Canada, Canadian Irradiation Centre
    Research article
    2020
    A research article on "Effect of ?-irradiation on the microbial inactivation, nutritional value, and antioxidant activities of infant formula"
    USA
    Journal Article
    2021
    Controlling the Colonization of Clostridium perfringens in Broiler Chickens by an Electron-Beam-Killed Vaccine
    Canada, Canadian Irradiation Centre
    Research article
    2020
    A research article on "Microbicidal effectiveness of irradiation from Gamma and X-ray sources at different dose rates against the foodborne illness pathogens Escherichia coli, Salmonella Typhimurium and Listeria monocytogenes in rice"
    Poland, INCT
    Research article
    2019
    A research article on "‘Zero energy’ electron beam technology for sludge hygienization"
    Germany, Fraunhofer Institute for Organic Electronics
    Research article
    2020
    A research article on "Low-Energy Electron Irradiation Efficiently Inactivates the Gram-Negative Pathogen Rodentibacter pneumotropicus-A New Method for the Generation of Bacterial Vaccines with Increased Efficacy"
    Canada
    Journal Article
    2020
    Radiosensitivity increase in FCV-F9 virus using combined treatments with natural antimicrobials and gamma-irradiation
    Canada
    Journal article
    2020
    Microbicidal effectiveness of irradiation from Gamma and X-ray sources at different dose rates against the foodborne illness pathogens Escherichia coli, Salmonella Typhimurium and Listeria monocytogenes in rice
    Canada, Canadian Irradiation Centre
    Research article
    2021
    A research article on "Radiosensitization of rice weevil Sitophilus oryzae using combined treatments of essential oils and ionizing radiation with gamma-ray and X-Ray at different dose rates"
    Portugal
    Journal Article
    2020
    Effect of Gamma-Radiation on Zearalenone— Degradation, Cytotoxicity and Estrogenicity
    Canada, Canadian Irradiation Centre
    Research article
    2020
    A research article on "Radiosensitivity of Feline Calicivirus F9 on Iceberg Lettuce Surface after Combined Treatments with ?-Radiation"
    Argentina, CNEA
    Book chapter
    2021
    Book chapter "MICROBIAL INACTIVATION IN ANIMAL WASTE WITH IONIZING RADIATION" in a book "MICROBIOLOGIA: CLINICA, AMBIENTAL E ALIMENTOS"
    Hungary, Institute for Energy Security and Environmental Safety
    Research article
    2021
    A research article on "Antibiotics in a wastewater matrix at environmentally relevant concentrations affect coexisting resistant/sensitive bacterial cultures with profound impact on advanced oxidation treatment"
    Poland
    Conference Paper
    2020
    NEW TRENDS IN ELECTRON BEAM ENVIRONMENTAL APPLICATIONS
    Poland
    Journal Article
    2019
    https://iaeacloud.sharepoint.com/:b:/r/sites/CRADocuments/CRPs/F23033%202220/Publications/POL1.pdf?csf=1&web=1&e=MoRZS4
    Germany
    Journal Article
    2018
    Low-energy electron-beam treatment as alternative for on-site sterilization of highly functionalized medical products – A feasibility study
    Portugal
    Journal Article
    2020
    The use of gamma radiation for extractability improvement of bioactive compounds in olive oil wastes
    Poland, INCT
    Conference presentation
    2020
    A conference presentation on "NEW TRENDS IN ELECTRON BEAM"
    USA
    Journal Article
    2020
    A critical review of ionizing radiation technologies for the remediation of waters containing Microcystin-LR and M. aeruginosa
    Argentina
    Conference Paper
    2019
    Inactivación microbiana en residuos de animales de laboratorio utilizando radiaciones ionizantes
    USA
    Journal Article
    2022
    Assessment of microbiological correlates and immunostimulatory potential of Electron Beam Inactivated Metabolically Active Yet Non Culturable (MAyNC) Salmonella Typhimurium
    Canada
    Journal Article
    2021
    Radiosensitization of rice weevil Sitophilus oryzae using combined treatments of essential oils and ionizing radiation with gamma-ray and X-Ray at different dose rates
    USA, TAMU
    Research article
    2020
    A research article on "Reduction in microbial infection risks from raw milk by Electron Beam Technology"
    Argentina, CNEA
    Conference presentation
    2019
    Presentationa at the IV Congreso Nacional de Ciencia y Tecnología Ambiental "Inactivación microbiana en residuos de animales de laboratorio utilizando radiaciones ionizantes"
    Argentina
    Journal article
    2021
    MICROBIAL INACTIVATION IN ANIMAL WASTE WITH IONIZING RADIATION
    Brazil, IPEN
    Research article
    2018
    A research article on "Emerging pollutants, related toxicity, and water quality decreasing: tannery, textile, and pharmaceuticals load pollutants"
    Canada
    Journal Article
    2020
    Radiosensitivity of Feline Calicivirus F9 on Iceberg Lettuce Surface after Combined Treatments with c-Radiation
    USA, TAMU
    Research article
    2019
    A research article on "A Comparative Analysis of the Metabolomic Response of Electron Beam Inactivated E. coli O26:H11 and Salmonella Typhimurium ATCC 13311"
    Canada, Canadian Irradiation Centre
    Research article
    2020
    A research article on "Microbial radiosensitization using combined treatments of essential oils and irradiation- part B: Comparison between gamma-ray and X-ray at different dose rates"
    Germany, Fraunhofer Institute for Organic Electronics
    Research article
    2019
    A research article on "Eimeria tenella oocysts attenuated by low energy electron irradiation (LEEI) induce protection against challenge infection in chickens"
    USA
    Journal Article
    2020
    Reduction in microbial infection risks from raw milk by Electron Beam Technology
    Poland
    Journal Article
    2019
    WYKORZYSTANIE PROMIENIOWANIA JONIZUJACEGO W OBRóBCE OSADóW Z OCZYSZCZALNI SCIEKóW. ?ZEROENERGETYCZNA” TECHNOLOGIA DO OBRóBKI OSADóW SCIEKOWYCH
    Canada
    Journal Article
    2020
    Microbial radiosensitization using combined treatments of essential oils and irradiation- part B: Comparison between gamma-ray and X-ray at different dose rates
    Hungary
    Journal Article
    2021
    Antibiotics in a wastewater matrix at environmentally relevant concentrations affect coexisting resistant/sensitive bacterial cultures with profound impact on advanced oxidation treatment
    Germany, Fraunhofer Institute for Organic Electronics
    Research article
    2018
    A research article on "Low-energy electron-beam treatment as alternative for on-site sterilization of highly functionalized medical products – A feasibility study"
    Germany
    Journal Article
    2020
    Automated application of low energy electron irradiation enables inactivation of pathogenand cell-containing liquids in biomedical research and production facilities
    Portugal, C2TN
    Research article
    2020
    A research article on "Ionizing Radiation Technologies to Increase the Extraction of Bioactive Compounds from Agro-Industrial Residues: A Review"
    USA, TAMU
    Research Article
    2021
    A research article on "Controlling the Colonization of Clostridium perfringens in Broiler Chickens by an Electron-Beam-Killed Vaccine"
    Canada, Canadian Irradiation Centre
    Research article
    2020
    A research article on "Radiosensitivity increase in FCV-F9 virus using combined treatments with natural antimicrobials and gamma-irradiation"
    Poland, INCT
    Report
    2019
    A report on "WYKORZYSTANIE PROMIENIOWANIA JONIZUJACEGO W OBRóBCE OSADóW Z OCZYSZCZALNI SCIEKóW. ?ZEROENERGETYCZNA” TECHNOLOGIA DO OBRóBKI OSADóW SCIEKOWYCH"
    Germany, Fraunhofer Institute for Organic Electronics
    Research article
    2020
    A research article on "Automated application of low energy electron irradiation enables inactivation of pathogen- and cell-containing liquids in biomedical research and production facilities"

    Contact CRP Officer

    CAPTCHA
    Introduzca los caracteres mostrados en la imagen.
    Esta pregunta es para comprobar si usted es un visitante humano y prevenir envíos de spam automatizado.
    午夜爱爱爱爱爽爽爽视频网站