Integrated Imaging (SPECT/CT; PET/CT; MRI) in Infection/Inflammation Spine Pathology
Closed for Proposals
Project Type
Coordinated Research ProjectProject Code
E13040
CRP
1990
Approved Date
13/09/2013Project Status
ClosedStart Date
13/09/2013Expected End Date
31/01/2018Completed Date
03/05/2019Description
Summary of the Background/Research Problem ? The prevalence of back pain has increased worldwide.? Low back pain is now the 6th most common cause for global disability-adjusted life years. ? There is likely an increase in spinal surgery in the future. ? The most serious complication after spinal surgery is spinal infection.? There remains uncertainty about the imaging modality of choice in the diagnosis of post-operative spinal infection.? There is therefore a clear need for research on imaging modality of choice in the diagnosis of post-operative spinal infection.? There has been a worldwide increase in hybrid imaging (SPECT/CT, PET/CT) and MRI.? Taken into account the above mentioned points, with and increasing prevalence of back pain in low-middle income countries, is likely going to translate -in the near future- into an increased incidence of spinal surgery, and the associated complications of it, of which infection at the surgical site is the most serious one. Therefore, a CRP to determine the imaging modality of choice for the diagnosis and assessment of post-operative spinal infection would be extremely beneficial to further improve health care delivery in member states.
Objectives
To assess the role of multimodality imaging (MRI, 99mTc-UBI SPECT/CT, [18F]FDG PET/CT) in the diagnosis of spinal infection after spinal surgery.
Specific Objectives
2 To determine if a specific imaging algorithm can be identified for the evaluation of spinal infection after spinal surgery.
1. To determine and compare the diagnostic performance of MRI, 99mTc-UBI SPECT/CT and [18F]FDG PET/CT in the evaluation of suspected infection of the spine after surgery.
Impact
This CRP have :
? Increase knowledge of the medical community about the use of imaging in the diagnosis and assessment of post-operative spinal infection.
? Strengthen Radiology and Nuclear Medicine practice for the evaluation of suspected spinal infection in the participating centres.
? Demonstrate that the diagnostic performance of [18F] FDG PET/CT was similar to that of MRI and should lead to a wider use of this metabolic imaging modality, especially in diabetic patients suspected of osteomyelitis.
? Proposed a diagnostic imaging algorithm for postoperative spinal infection.
Relevance
Although 99mTc-UBI SPECT/CT was found to be disappointing and the most accurate imaging modality between MRI and [18F]FDG PET/CT remains uncertain, this CRP confirmed the importance of early diagnosis of post-operative spinal infections and the critical role played by imaging techniques.