Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry
Closed for Proposals
Project Type
Coordinated Research ProjectProject Code
E21007
CRP
1528
Approved Date
30 October 2008Project Status
ClosedStart Date
11 June 2009Expected End Date
11 June 2014Completed Date
15 July 2015Description
Nuclear Medicine instruments have the potential to provide quantitative information and its distribution with time. This information provides the basis for internal dosimetry and is needed to properly optimize the use of any radiopharmaceutical. Patient specific dosimetry is often a legal obligation when administering radiopharmaceuticals for therapy. There are, however, no harmonized protocols or guidelines for acquiring quantitative information from Nuclear Medicine instruments. Nor are there documents that address the possibilities and limitations of these instruments for quantitative information. This CRP aims at addressing this gap.
Objectives
The overall objective of this project is to assist Member States in accurately determining radionuclide distributions for diagnostic and therapeutic nuclear medicine.
Specific Objectives
Assess the need for standardisation and harmonisation of quantitative nuclear medicine
Assess the need for training in the field of absolute quantitation and internal dosimetry
Determine the achievable accuracy of absolute activity quantitation for different nuclear medicine methodologies
in a range of sites with various levels of available resources
Develop and test quantitative imaging methods in nuclear medicine practice
Impact
1) The publication on Quantitative Nuclear Medicine Imaging (IAEA Human Health Reports No. 9) has been very popular in the Member States.
2) Through this CRP research networks were developed. The collaboration of the participants continues even after the end of the CRP.
3) The journal paper with the results of the Ba-133 intercomparison has received a lot of interest in the nuclear medicine medical physics community.
Relevance
The topic of the CRP is of continuous relevance with the objectives of the project 2.2.4.3, as it provides guidance to Member States to apply advanced and accurate dosimetry practices in therapeutic nuclear medicine.
CRP Publications
German and Austrian Society of Medical Physics and the Swiss Society of Radiobiology and Medical Physics
Zeitschrift für Medizinische Physik
2016
International multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification