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  • Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry

    Closed for proposals

    Project Type

    Coordinated Research Project

    Project Code

    E21007

    CRP

    1528

    Approved Date

    30 October 2008

    Status

    Closed

    Start Date

    11 June 2009

    Expected End Date

    11 June 2014

    Completed Date

    15 July 2015

    Description

    Nuclear Medicine instruments have the potential to provide quantitative information and its distribution with time. This information provides the basis for internal dosimetry and is needed to properly optimize the use of any radiopharmaceutical. Patient specific dosimetry is often a legal obligation when administering radiopharmaceuticals for therapy. There are, however, no harmonized protocols or guidelines for acquiring quantitative information from Nuclear Medicine instruments. Nor are there documents that address the possibilities and limitations of these instruments for quantitative information. This CRP aims at addressing this gap.

    Objectives

    The overall objective of this project is to assist Member States in accurately determining radionuclide distributions for diagnostic and therapeutic nuclear medicine.

    Specific objectives

    Assess the need for standardisation and harmonisation of quantitative nuclear medicine

    Assess the need for training in the field of absolute quantitation and internal dosimetry

    Determine the achievable accuracy of absolute activity quantitation for different nuclear medicine methodologies
    in a range of sites with various levels of available resources

    Develop and test quantitative imaging methods in nuclear medicine practice

    Impact

    1) The publication on Quantitative Nuclear Medicine Imaging (IAEA Human Health Reports No. 9) has been very popular in the Member States.
    2) Through this CRP research networks were developed. The collaboration of the participants continues even after the end of the CRP.
    3) The journal paper with the results of the Ba-133 intercomparison has received a lot of interest in the nuclear medicine medical physics community.

    Relevance

    The topic of the CRP is of continuous relevance with the objectives of the project 2.2.4.3, as it provides guidance to Member States to apply advanced and accurate dosimetry practices in therapeutic nuclear medicine.

    CRP Publications

    Type

    XLII Congresso Brasileiro de Radiologia & XXVII Congresso Brasileiro de Medicina Nuclear, Curitiba, October 10-12, 2013

    Year

    2013

    Description

    Intercomparación de la cuantificación de imágenes en centros de Medicina Nuclear de América Latina. Resultados preliminaries

    Country/Organization

    Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, Brazil

    Type

    Phys Med Biol, 2015; 60:1325-1337

    Year

    2015

    Publication URL

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437762/

    Description

    Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source

    Country/Organization

    USA

    Type

    Human Health Report

    Year

    In the editorial process

    Description

    Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods

    Country/Organization

    IAEA

    Type

    Bangladesh Journal of Nuclear Medicine, Vol. 15, No. 1, January 2012, p. 22-25

    Year

    2012

    Description

    Quantitative Study of Hyperthyroid Patient by Employing Different Protocols at the Institute of Nuclear Medicine and Ultrasound (INMU)

    Country/Organization

    Society of Nuclear Medicine, Bangladesh

    Type

    8th International Congress of the Croatian Society of Nuclear Medicine, ?ibenik, May 9–12, 2014

    Year

    2014

    Description

    Activity Quantification of 133Ba Sources In Water Phantom

    Country/Organization

    Croatian Society of Nuclear Medicine

    Type

    2013 Society of Nuclear Medicine and Molecular Imaging Meeting (Vancouver, Canada)

    Year

    2013

    Description

    Stability of activity quantification in SPECT/CT

    Country/Organization

    Society of Nuclear Medicine

    Type

    Bangladesh Journal of Nuclear Medicine, Vol. 17, No. 2, July 2014, p. 134:137

    Year

    2014

    Description

    Quantification of Patient Specific Dosimetry in Radionuclide Therapy: A Phantom Study

    Country/Organization

    Society of Nuclear Medicine, Bangladesh

    Type

    Bangladesh Journal of Nuclear Medicine Vol. 17, No. 1, January 2014, p. 80

    Year

    2014

    Description

    Ba-133 Phantom study to evaluate image based patient specific dosimetry in radionuclide therapy

    Country/Organization

    Society of Nuclear Medicine, Bangladesh

    Type

    Journal of research of the National Institute of Standards and Technology

    Year

    2013

    Publication URL

    http://nvlpubs.nist.gov/nistpubs/jres/118/jres.118.017.pdf

    Description

    Calibration of Traceable Solid Mock 131I Phantoms Used in an International SPECT Image Quantification Comparison

    Country/Organization

    National Institute of Standards and Technology, Gaithersburg, USA

    Type

    26th EANM Annual Congress, Lyon, October 19-23, 2013

    Year

    2013

    Description

    Effect of calibration source geometry on shape on absolute activity quantification in SPECT

    Country/Organization

    European Association of Nuclear Medicine

    Type

    2013 Society of Nuclear Medicine and Molecular Imaging Meeting (Vancouver, Canada)

    Year

    2013

    Description

    Accuracy and repeatability of quantitative 131-I SPECT: phantom design and benchmark results

    Country/Organization

    Society of Nuclear Medicine

    Type

    13th IRPA International Congress, Glasgow, May 14-18, 2012

    Year

    2012

    Publication URL

    http://www.irpa.net/members/TS7b.5.pdf

    Description

    Optimization of a routine method for bone marrow dose estimation in 177Lu-EDTMP therapy: Experience in Uruguay

    Country/Organization

    International Radiation Protection Association

    Type

    SNMMI Annual Meeting, St. Louis, USA, June 7-11, 2014

    Year

    2014

    Publication URL

    http://jnumedmtg.snmjournals.org/cgi/content/short/55/1_MeetingAbstracts/55

    Description

    International intercomparison of absolute quantification in nuclear medicine

    Country/Organization

    Society of Nuclear Medicine

    Type

    28th EANM Annual Congress, Hamburg, October 10-14, 2015

    Year

    2015

    Description

    International Multicentre Evaluation of Absolute Quantification in Planar and SPECT Imaging

    Country/Organization

    European Association of Nuclear Medicine

    Type

    13th Asia-Oceania Congress of Medical Physics & 11th South-East Asian Congress of Medical Physics, Singapore, December 12-14, 2013

    Year

    2013

    Description

    Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry: IAEA Coordinated Research Project

    Country/Organization

    Asia-Oceania Congress of Medical Physics & South-East Asian Congress of Medical Physics

    Type

    Bangladesh Cancer Congress, Dhaka, Bangladesh, August 22-23, 2014

    Year

    2014

    Description

    Image Based Patient Specific Dosimetry in Radionuclide Therapy: A Phantom Study

    Country/Organization

    Oncology Club, Bangladesh

    Type

    ARCCNM/KSNM International Symposium, October 24-27, 2012, Seoul, Korea

    Year

    2012

    Description

    Quantification of Thyroid Uptake with Gamma Camera Images

    Country/Organization

    Asia Oceania Federation of Nuclear Medicine and Biology and Korean Society of Nuclear Medicine

    Type

    Bangladesh Journal of Nuclear Medicine, Vol. 16, No. 1, January 2013, p. 41-44

    Year

    2013

    Description

    Quantification of Thyroid Activity Using Conjugate View Method with Gamma Camera Images

    Country/Organization

    Society of Nuclear Medicine, Bangladesh

    Type

    XIII Congreso de ALASBIMN, 28 September – 1 October, 2011

    Year

    2011

    Description

    Evaluación dosimétrica pre-terapéutica de 177Lu-DOTA-TATE en pacientes con tumores neuroendócrinos en Uruguay

    Country/Organization

    Asociación Latinoamericana de Sociedades de Biología y Medicina Nuclear

    Type

    Journal of Nuclear Medicine, 2013, 54.supplement 2: 2061-2061

    Year

    2013

    Publication URL

    http://jnm.snmjournals.org/content/54/supplement_2/2061

    Description

    Factors affecting repeatability of activity quantification in SPECT/CT

    Country/Organization

    Society of Nuclear Medicine

    Type

    4th International Conference on Radiopharmaceutical Therapy, Ho Chi Minh City, Vietnam, November 28 – December 2, 2011

    Year

    2011

    Description

    Quantitative Study of the Different Protocols Analysis for Excess Radiation Absorbed Doses from Radioiodine Treatment of Hyperthyroidism in Bangladesh

    Country/Organization

    Bangladesh

    Type

    Zeitschrift für Medizinische Physik

    Year

    2016

    Publication URL

    http://www.sciencedirect.com/science/article/pii/S0939388916300034

    Description

    International multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification

    Country/Organization

    German and Austrian Society of Medical Physics and the Swiss Society of Radiobiology and Medical Physics

    Type

    Radiation protection dosimetry, 2010, 141.1: 50-55

    Year

    2010

    Publication URL

    https://rpd.oxfordjournals.org/content/141/1/50.full

    Description

    The determination of patient dose from 18F-FDG PET/CT examination

    Country/Organization

    Thailand

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